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KMID : 0191120120270091120
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Journal of Korean Medical Science
2012 Volume.27 No. 9 p.1120 ~ p.1123
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Ceftiaxone-Induced Neurotoxicity: Case Report, Pharmacokinetic Considerations, and Literature Review
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Kim Ki-Bae
Kim Sun-Moon
Park Woo-Ri
Kim Ji-Seon
Kwon Soon-Kil
Kim Hye-Young
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Abstract
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Ceftriaxone is widely used in patients for the treatment of serious gram-negative infections. Ceftriaxone can induce some potential side effects, including neurotoxicity, however, nonconvulsive status epilepticus has rarely been reported. We report a case of acute reversible neurotoxicity associated with ceftriaxone. A 65-yr-old woman with chronic kidney disease developed altered consciousness during ceftriaxone treatment for urinary tract infection. The electroencephalogram demonstrated continuous bursts of generalized, high-voltage, 1 to 2 Hz sharp wave activity. Neurologic symptoms disappeared following withdrawal of ceftriaxone. The possibility of ceftriaxone-induced neurotoxicity should be considered in patients developing neurological impairment during ceftriaxone use, and the discontinuation of the drug could lead to complete neurological improvement.
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KEYWORD
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Ceftriaxone, Cephalosporins, Chronic Kidney Failure, Seizures
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